Endocannabinoids are molecules that, like the plant cannabinoid THC, bind to and trigger cannabinoid receptors. However, unlike THC, endocannabinoids are produced naturally by cells in our body (“endo” means “within, ” as in within the body). buy CBD oil UK
There are two major endocannabinoids: anandamide and 2-AG (Figure 2). These endocannabinoids are produced from fat-like molecules within cell filters, and are synthesized on demand. This means that they get made and used exactly when they’re needed, rather than packaged and stored for later use like many other neurological molecules.
The 3rd piece of the endocannabinoid triad includes the metabolic enzymes that quickly damage endocannabinoids once they are used. The two big enzymes are FAAH, which breaks down anandamide, and MAGL, which breaks down 2-AG (Figure 3). These types of enzymes ensure that endocannabinoids get used when they’re needed, however, not for much longer than necessary. This differentiates endocannabinoids from a number of other molecular signals in the body, such as hormones or classical neurotransmitters, which can persist for many secs or minutes, or get packaged and stored for later use.
The 3 key components of the ECS is found within almost every major approach to the body. When something brings a cell away of its Goldilocks region, these three pillars of the ECS are often called after to bring things back, thus keeping homeostasis. Due to its role in helping bring things back again to their physiological Goldilocks zone, the ECS is often engaged only when and where it’s needed. Doctor Vincenzo Di Marzo, Research Director at the Institute of Biomolecular Hormone balance in Italy, put it to us this way:
“With the ‘pro-homeostatic action of the ECS’ we mean that this product of chemical signals gets in the short term activated following deviations from cellular homeostasis. When such deviations are non-physiological, the temporarily activated ECS endeavors, in a space- and time-selective manner, to bring back the previous physiological situation (homeostasis). ”
In other words, the ECS helps bring things to the organic Goldilocks zone.
Below we will consider examples of how the ECS helps maintain homeostasis in two areas: the firing of brain cells in the nervous system, and the inflammatory response of proof system.
Head cells (neurons) communicate by sending electrochemical signals with each another. Each neuron must listen to their partners to choose whether it will fire off it is own signal at any given moment. However, neurons can’t stand to get too much input–there’s a Goldilocks zone. If they get overloaded by signals, it can be toxic. Which where endocannabinoids come in.